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It has been shown to be reduced in expression in AMs from healthy smokers and COPD smokers when compared with never smokers.38 CD31 (platelet endothelial cell adhesion molecule) is a surface marker that has been reported to promote tethering of apoptotic cells and is reduced in AMs from smokers.38 Blocking of CD91 and CD31 has shown to reduce AM efferocytosis.38 CD44 is involved in clearing of hyaluronan, lipid metabolism, surfactant processing and efferocytosis, all which have a role in regulating inflammation