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The process as claimed in claims 1 and 6, wherein the conversion of a peptide having amino acid sequence His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu- Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly to Semaglutide is carried out by global deprotection of the compound to cleave the peptide chain from the Resin and deprotection of the protected amino acids by using cocktail mixture/cleaving reagent and reacting the obtained compound with compound of formula-3 in a solvent optionally in presence of a base and/or a coupling agent

Chronic 16-day administration resulted in an average 8.6% decrease in body weight relative to baseline, with a 13.8% relative weight loss compared to vehicle controls

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"I couldn't even lift a water bottle," she said