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As CRP is not deemed to have a causal role in cancer [37] we additionally adjusted for hs-CRP only in sensitivity analyses

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Scientific knowledge about the pharmacological actions of exogenous cannabinoids was considerably informed by the discovery of the G protein-coupled cannabinoid receptors (CB 1 and CB 2 ) and their endogenous ligands known as endocannabinoids (anandamide and 2-arachidonoylglycerol (2-AG)) which, along with their synthesis/degradation enzymes, collectively constitute the endocannabinoid system

These cytokines contribute to systemic inflammation and play a role in the evolution of multi-organ dysfunction (Hunter and De Plaen, 2014

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