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Because e-cigarettes do not burn tobacco, the reduction of harmful substances depends on the chemical composition of the e-liquid, as well as the characteristics of the device 4,5,15,47,48,49

Both respiratory failure and an exaggerated inflammatory response seem to be the key findings of EVALI

Even small leaks hidden behind walls can create serious problems over time

However, as demand grew, relying solely on manual packaging became unsustainable

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