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The ACC also supports the use of GLP-1R agonists for cardiovascular risk reduction in patients with T2DM and multiple ASCVD risk factors, independent of glucose control or background antihyperglycemic therapy [122]

Oxidized GSH (GSSG) is reduced back to GSH by GSR in an NADPH-dependent manner, thereby sustaining cellular antioxidant defense and linking redox buffering to central metabolic pathways that generate NADPH, such as the PPP and IDH-dependent reactions

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Colucci S, Mori G, Vaira S, Brunetti G, Greco G, Mancini L, Simone GM, Sardelli F, Koverech A, Zallone A, Grano M: L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro

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