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And, while the actual rates of smoking-related cancers from 2006 to 2016 declined (annual percent change (APC) = 0.8, 95% CI = 1.0 to 0.5%), under the scenario of smoking elimination, the trend in cancer incidence at these sites was not declining (APC = 0.1, 95% CI = 0.4 to + 0.1%)

It is important to note that, while a substantial proportion of these vape-specific stores could have already existed prior to the licensure requirement taking effect, the study nevertheless observed a significant increase in the number of vape-specific stores even after 2016, including a substantial increase in 2017 indicating that popularity of these stores may have increased irrespective of licensure requirements

Because most RYO users roll less than 0.8 grams of tobacco per cigarette, using as little as 0.5 grams per cigarette, 58 RYO tobacco provided a cheaper alternative to factory-made cigarettes (attracting less excise per cigarette)