Muscle Mass and Body Composition Research in growth hormone-deficient and intact animal models showed effects on lean body mass: 15.3% increase in body weight in GH-deficient mice treated with ipamorelin over 9 weeks Enhanced protein synthesis and nitrogen retention in skeletal muscle tissue Dose-dependent effects on body weight gain and lean mass accretion Preserved muscle mass during catabolic conditions in experimental models Studies using DEXA scanning confirmed increases in lean tissue mass with corresponding reductions in fat mass percentage
Ethics statement The studies involving human participants were reviewed and approved by Institutional Review Board at Nova Southeastern University in Fort Lauderdale, FL, USA
doi:10.1016/S0891-5849(99)00177-X
[1] In adults with confirmed GH deficiency, sermorelin may also be considered as a treatment option, although its use in healthy older adults for anti-aging purposes remains unproven and is not an FDA-approved indication
The receptor was first incubated with the isolated G protein and, when applicable, the ligand (10 M) for 30 min in a 25 mM HEPES, 100 mM NaCl, 5 mM MgCl 2 , pH 7.5 buffer
