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Eligibility criteria for selecting studies Prospective cohort studies with at least 50 events, reporting hazard ratios or relative risks (both hereafter referred to as relative risk) compared with never smokers or age specific incidence in relation to risk of coronary heart disease or stroke
According to the CDC, adult e-cigarette usage in the U.S
One such method requires frequency counts in each exposure group and assumes that adjusted relative risks are similar to unadjusted ones.88 However, frequency data were not reported for many studies, and it is essential to use age adjusted relative risks because age is an important confounder for cardiovascular disease
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