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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

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A citrate buffer system was used for p H 2.0 to 6.0, KH 2 PO 4 /Na 2 HPO 4 for p H 6.5 to 8.0, and Na 2 B 4 O 7 for pH 8.5 to 10.0

In the phase 2 clinical trial of Eli Lillys retatrutide, the drug showed a notable weight reduction effect, with an average of 17.5% loss in body weight over a 24-week period

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