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FIGURE 4 Nuclear factor erythroid 2-related factor (NRF2) is an accepted master regulator participating in the cellular adaptive response to redox or energy stress, which accumulates in nuclear to induce a battery of defensive genes encoding detoxifying enzymes and antioxidant proteins (such as SOD2 and NFB) (Figure 4E) (Tonelli et al., 2018)

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Dual agonist research focuses on compounds designed to interact with two receptor systems rather than one