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Meaning his extraordinary output was truly pure, truly his vision and not filtered through a host of PR agencies, managers and business people: an artist living the life he wanted to live, on his terms, making the work he wanted to make

This over abundance greatly increased the frequency of his smoking

The top comes off making it very easy to empty

Trials of combination NRT were used to inform this estimate because: (1) randomized trials of a high-dose nicotine patch are not available to inform the projected treatment size, and (2) similar to nicotine patch, combination NRT also allows upward titration to reach satiety

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