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Studies have theorised that L-carnitine is a compound that plays an important role in this process of fat metabolism as its key role is to transport the long-chain fatty acids across the inner membrane

While many studies provide evidence that the gut microbiota is engaged with in reciprocal crosstalk with the HPA-axis, the mechanism behind this interaction remains to be elucidated [71]

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Thus, targeting of the transporters expressed only at the BBB would be useful in terms of delivery of drugs with extracellular targets in the brain, while utilization of the transporters expressed at the BBB and cellular membrane of the brain parenchymal cells is essential for delivery of the drugs with intracellular targets

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