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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

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Integrative analyses showed associations between microbial composition and host gene expression, such as CD74 positively correlated with Lactobacillus and PPP1R3C negatively with Bacteroidota, suggesting that smoking-induced microbial shifted might interact with host transcriptional programs to promote OSCC progression [59]

The bans seem to be having an impact

Since then, researchers have identified additional lung-cancer driver mutations that are more common in never-smokers than smokers 1