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This combination of excess acid and a weakened valve increases the risk of reflux

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3, 4, 6-9 Impact of mood and environment Drugs that affect a persons mental state (psychoactive drugs) can also have varied effects depending on a persons mood (often called the set) or the environment they are in (the setting): Set : a persons state of mind, previous encounters with the drug, and expectations of whats going to happen

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Intravenous self-administration: response rates, the effects of pharmacological challenges, and drug preferences