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Smoking can cause clogged arteries by damaging the blood vessels, increasing inflammation, raising blood pressure, and making it easier for plaque to build up inside the arteries

Introduction, conclusions, and historical background relative to E-Cigarettes

BMC Pulmonary Medicine 15(1):120

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44-47 These effects of lower exposure manifest as reduced disturbances in biological processes associated with COPD (including oxidative stress, inflammation, and apoptosis), less severe adaptive changes in respiratory tissues, absence of alveolar destruction (emphysema), and reduced pulmonary dysfunction