Orlistat works locally in the digestive system by blocking fat absorption, whilst Wegovy (semaglutide) works systemically through the brain and gut to reduce appetite, slow gastric emptying, and improve metabolic control
Lincoff noted that this trial wasnt focused on weight management, where trials typically involve changes in diet and exercise and close monitoring, but instead models the way cardiovascular disease is treated in the real world. He also noted that not all of the participants got the highest dose of Wegovy in this study
Units treated like milligrams: syringe marks measure volume and depend on concentration
According to American Thyroid Association guidelines, treatment is typically initiated when TSH rises above 10 mIU/L or when TSH is between 4.5-10 mIU/L with symptoms or positive thyroid antibodies
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