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An analysis of the H 4 R-G i interaction shows that the hydrophobic interactions between a cluster of hydrophobic residues L353 G.H5.25 , L348 G.H5.20 , I344 G.H5.16 , I343 G.H5.15 and a patch of the hydrophobic surface formed by L308 6.40 , L305 6.37 , L301 6.33 , L201 5.65 , I197 5.61 of the H 4 R is the main driver (Fig
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