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In addition to metabolic pathways, the upregulated genes were also associated with signaling pathways governing cellular growth, survival, differentiation, and endocrine homeostasis

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A study by Stanley and colleagues evaluated tesamorelin in overweight and obese adults without HIV and found significant VAT reductions, improvements in triglycerides, and increased IGF-1 mirroring the HIV-trial outcomes.[4] This is directly relevant for patients with metabolic syndrome and abdominal obesity who share the underlying pattern: suppressed GH-axis activity, excess visceral fat, dyslipidemia, and insulin resistance