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[150] The birth of this evidence-based and systematic approach has resulted in the reinforcement of tobacco taxes and the implementation of smoke-free laws in 128 countries that led to the decrease of smoking prevalence in developing nations

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So why is it so hard to stop smoking

M A Bittoni J Oncol Res Ther 2024 Both cigarette smoking and e-cigarette use induce epigenetic changes that are predictive of carcinogenesis

This can cause narrowing of the esophagus which results in obstruction of food passage, and may also cause alterations in the esophageal cells which may contribute to cancer