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Endocannabinoid Pathways and the Benefits of CBD vs THC The endocannabinoid system operates through retrograde signalinga fancy term for backward communication. Unlike most neurotransmitters that flow from sender to receiver, endocannabinoids travel backward, telling the sending neuron to slow down or stop

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Constricted Blood Vessels - As nicotine constricts your blood vessels, it increases the risk of hypertension, heart attack, and stroke