This decrease in fertility in the offspring of treated female rats was not evident at an oral dose of 3 mg/kg/day (9 times the MRHD exposure based on AUC at 1 mg twice daily)
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Nicotine induces brain CYP enzymes: relevance to Parkinsons disease, Parkinsons Disease and Related Disorders
19 mentioned a significant difference in cessation between groups, though without adequate data for effect size calculation
These are radioactive elements that are found in the fertilizer used to grow tobacco