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Innovative therapeutic strategies based on GLP-1 receptor agonists (GLP-1RAs), such as tirzepatide, fixed-ratio combinations of GLP-1RA with basal insulin, combinations of GLP-1RA with sodium-glucose cotransporter-2 inhibitors (SGLT-2i), and high-dose GLP-1RAs, have been listed as one of the most effective options for the treatment of type 2 diabetes

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