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showed that the extract from electronic cigarettes (containing different flavours and nicotine quantity) applied to cultured myocardial cells at different dilution, both with or without nicotine, was cytotoxic at different concentrations irrespective of nicotine presence

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And that in itself is, like, a new challenge for regulators who always had to be reactive in one way or another but now are finding that so many new technologies get introduced and widely adopted in a way that makes them really hard to put back in the bottle