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It doesnt always cause symptoms, but can increase the risk of developing GERD and symptoms like heartburn, chest pain, difficulty swallowing, and belching

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1 2 "Nicotine without smoke: Tobacco harm reduction"

Physicians are advised that bupropion also is contraindicated for patients with a history of anorexia or bulimia nervosa and should be used with extreme caution in severe liver cirrhosis