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The safety was preliminarily verified: The acute toxicity test showed that a single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice

B12 injections are clinically indicated for patients with confirmed deficiency or malabsorption conditions, including those with pernicious anaemia, gastrectomy, ileal resection, Crohn's disease, or neurological symptoms related to B12 deficiency

In a group of patients who had antibodies to tesamorelin after 26 weeks of treatment (56%) and were re-assessed 6 months later, after stopping EGRIFTA treatment, 18% were still antibody positive

Some Medicaid plans provide coverage, but restrictions apply

Until regulatory pathways evolve or academic institutions prioritize this research, human trial data will remain sparse