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Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function

a higher-concentration subcutaneous formulation followed in June 2021 for chronic weight management, with a cardiovascular indication added after the SELECT trial

June 12, 2025

Traditional methods like bariatric surgery, dietary supplements, and off-label prescribing of anti-obesity medications had their limitations