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Richie JP Jr, Das A, Calcagnotto AM, Aliaga CA, El-Bayoumy K

7 8 NAC's effectiveness as a glutathione precursor does not require high plasma NAC concentrations: once cysteine reaches the target cell, the synthesis machinery uses it efficiently

M.WanL.FrancisD

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In fact, defective mitophagy in macrophages strongly exacerbated NLRP3 activation, showing that mitochondria removed by this mechanism is a key regulator of inflammasome activity (Swanson et al