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As Oliver Kershaw of Vaping.com notes, diacetyl is, in a sense, the monosodium glutamate flavor-enhancer of vaping. But then, around 2010, a growing number of vapers became aware that some of their favorite e-liquids contained diacetyl and that this posed a health risk, so manufacturers started asking their flavoring suppliers to remove diacetyl from the formulas they ordered, and began making claims that their juices were diacetyl-free

Multiple medical organizations have asked the FDA to remove them from the market during the review period

Nicotine addiction plays a significant role in this progression, as it increases the likelihood of experimenting with other nicotine products