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Most were women (78.6 percent), with an average age of 52.7 years

One curious characteristic of the Spitz tumor pathway is inactivation of CDKN2A (often the only genetic alteration), with loss of p16 expression, which would be of concern in melanocytic tumors in any other pathway.47 Therefore, malignant transformation requires other mutations in addition to inactivation of CDKN2A, for example, TERT promoter mutations

VLDL-C, very low-density lipoprotein cholesterol

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