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Tirzepatide is a dual GLP-1/GIP receptor agonist, activating both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors simultaneously

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Dysesthesia, an abnormal sensation often described as tingling, burning, or numbness in the skin, appeared in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

While these medications provide promising results, they also carry potential side effects, such as gastrointestinal discomfort and a rare risk of pancreatitis

Drinking consistently throughout the day helps protect kidney function