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10.1016/j.oooo.2022.08.004 5 AlrawiS

277,285 To mitigate UA-induced endothelial dysfunction and inflammation, targeting the RAGE signaling pathway offers a promising therapeutic strategy

The ongoing PreVitaCOV Phase III trial (NCT05638633) at Wrzburg University Hospital in Germany is actively evaluating the efficacy of high-dose neurotropic B-vitamins (including 50 mg of active B6) in treating the extreme fatigue, dyspnea, and cognitive deficits of Post-COVID Syndrome

27 However, when potential initiating events were investigated, the authors provided evidence that erastin inhibits system X c -, a Na + -independent cystine/glutamate antiporter responsible for cystine uptake into the cell, thereby promoting glutathione synthesis