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Re-escalation to 2.4 mg once weekly may be considered if the lower dose is tolerated

Semaglutide has a weekly dosing schedule , meaning its effects are sustained over time rather than spiking daily

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As can be seen from a comparison of example 6 and comparative example 2, the use of Boc-His (Boc) -Aib-OSu dipeptide greatly increased the reaction time, reducing the conversion of the coupling reaction over the same time