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doi: 10.1172/JCI72434

As a novel multi-agonist peptide, it acts on GLP-1, GIP, and glucagon receptors, three key pathways involved in appetite regulation, glucose metabolism, and fat utilization

Furthermore, in ECL1 of GCGR there are two glycine residues (G207 ECL1 , G219 ECL1 ) that disconnect the helical structure in the active state, whereas the G219 ECL1 is not conserved in GLP-1R and the helical conformation is relatively intact in this region of GLP-1R

While lyophilized Retatrutide Raw Powder shows less immediate photosensitivity than reconstituted solutions, cumulative light exposure during extended storage periods can contribute to gradual potency loss through photodegradation mechanisms affecting sensitive molecular regions

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