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These processes involve (1) enhancing inflammatory responses by activating NF-B, IL-8, COX-2, IL-1, IL-6, TNF, IFN- , KC, MCP-1, 5-lipoxygenase, LTB4, and MMP, resulting in tissue damage and inflammation (114, 115)

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells

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Elevated SUA activates endothelial NF-B signaling, upregulating monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule-1 (ICAM-1) expressions to accelerate atherosclerosis progression (Wang H