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Circulating cytokines crossing the permeable BBB disrupt depression-associated brain signaling (92), suggesting that lipid dysregulation-induced BBB dysfunction facilitates aberrant peripheral-CNS communication, contributing to inflammation-driven depressive behaviors

Ghosh-Swaby OR, Goodman SG, Leiter LA, Cheng A, Connelly KA, Fitchett D, Jni P, Farkouh ME, Udell JA

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Notably, the mechanism effectively avoids the formation of alkyl radicals or byproducts, which are typically associated with radical reactions involving acyl radicals

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