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Serious effects are uncommon and mainly linked to unregulated, high-dose, or non-sterile use

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Another phase I trial (NCT00882674) in women with operable breast cancer and a phase II trial (NCT00796107) of R1507 in combination with letrozole in women with advanced breast tumors have finished, with results pending publication

Conventionalized animals show significant protection to APAP induced toxicity compared to their germ-free counterparts (Fig