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The integration of gustatory sensory signals occurs primarily in the orbitofrontal, prefrontal, and insular cortex ( ob/ob mice and diet-induced obesity models ( 5 The role of glucagon like peptide-1 (GLP-1) in taste receptor cells 5.1 Overview of GLP-1 and GLP-1RAs As it is broadly known, GLP-1 is a peptide hormone generated through the enzymatic breakdown of preproglucagon (PPG), ultimately giving rise to GLP-1 (137) and GLP-1 (736) amide or GLP-1 (737) peptide variants