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The upregulation and activation of 7nAChR subsequently activate several signaling pathways, including neuroprotective PI3K/Akt and Nrf2 pathways, then suppression of pro-apoptotic caspase-3, and suppression of NF-B that reduce the expression of proinflammatory cytokines such as IL-1, and TNF- [50, 86]

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Autistic-like behaviors are attenuated by agmatine consumption during pregnancy: assessment of oxidative stress profile and histopathological changes in the prefrontal cortex and CA1 region of the hippocampus

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