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Mice lacking the neuropeptide -calcitonin gene-related peptide are protected against diet-induced obesity

When symptoms do occur, they are typically non-specific and may include: Fatigue and general malaise Right upper quadrant discomfort or a sensation of fullness Mild hepatomegaly (enlarged liver) detected on examination NICE guidelines (NG49) recommend that NAFLD should be suspected in individuals with metabolic risk factors, particularly those with type 2 diabetes, obesity (BMI 30 kg/m), or metabolic syndrome

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doi: 10.2353/ajpath.2009.081011 3 BonettR

Oligomeric and fibrillar species of amyloid- peptides differentially affect neuronal viability