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We also address current barriers to implementation and evidence-based use, ongoing clinical trials, and future directions, including combination therapies that may enhance efficacy and patient outcomes

doi:10.1016/S0021-9258(18)53812-6

Some practitioners are exploring whether the two may complement each other for comprehensive metabolic support

In addition to peripheral effects, certain hepatokines, such as FGF-21, SELENOP, Fetuin-A, ANGPTL3, MANF, Adropin, ApoJ, and SHBG, exhibit direct or indirect effects on the CNS and represent promising therapeutic targets for AD (Figure.2)