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The authors call for further research to evaluate clinical outcomes of HS patients treated with GLP-1 agonists, including effects on disease severity, weight management, and metabolic health

Pregnancy or Planning Pregnancy No safety data in pregnancy Must stop at least 2 months before attempting conception 4

Switching medications The effect of GLP-1 medications varies from person to person

It was diagnosed using the Fifth Edition Standards in the 2010 WHO laboratory manual for the examination and processing of human semen [1]

From a pathophysiological perspective, DS involves a complex interplay of mechanical factors associated with the accelerated transit of osmotically active gastric contents into the small intestine, alterations of the enteric nervous system (ENS), and disruptions in the hormonal profile of the gastrointestinal tract (GIT) [6,7,8]