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Its a project which might seem overwhelming

Mixing drugs at high doses is probably going to give you a higher likelihood of having an adverse effect, than just having one drug at a high concentration, Sodergren says

44 Second, characteristics of smokers for the smoking cessation analyses were only assessed in 1998 and were not time-varying

This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used

They found particular molecular fingerprints of DNA damage called mutational signatures in the smokers DNA, and counted how many of these particular mutations were found in the different tumours