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Niacinamide acts further downstream by limiting melanosome transfer from melanocytes to keratinocytes, thus reducing pigment dispersion within the epidermis

This is the opposite of the antagonistic relationship seen with ibuprofen

The double mutant pcs1pcs2 impaired in phytochelatin synthesis and the catabolism of glutathione conjugates 61,62 showed also a WT-like phenotype when exposed to AITC

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