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The pericytes notably have an impact on the number of tight junctions and the polarization of the astrocytes

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They can also form from chemical changes during synthesis or storage

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Chronic stress reshapes the gut ecosystem: SCFA-producing bacteria decline mucosal barrier integrity weakens inflammatory cytokines rise serotonin production drops microbial diversity collapses This leads to: stronger cravings weaker self-regulation unstable blood sugar reward-seeking eating low-mood snacking This is one reason broader discussions around leaky gut and microbiome support often overlap with stress-related appetite, inflammation, and microbiome research