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Han J, Miyamae Y, Shigemori H, Isoda H (2010) Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1

11, 29 Although it is unclear whether the accumulation of iron in the brain is primary or secondary to the development of neurodegenerative disorders, 30 one animal study has shown that unilateral injection of FeCl 3 into the substantia nigra of adult rats results in a 95% decrease of striatal dopamine, which impaired dopamine-related behavioral responses

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