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FDA Compliance Alert for Weight Management Providers: Compounded GLP-1s with Additives

Given the significant unmet need for novel therapeutic interventions in AS, particularly as many patients still progress to KF despite current treatments like RASi, GLP-1 RAs may offer an innovative strategy to delay KF in AS, potentially addressing both metabolic and inflammatory pathways involved in CKD progression [40, 42, 56]

Compounded sublingual semaglutide is associated with a much lower risk of overdose

Research suggests semaglutide may have enhanced ability to cross the blood-brain barrier compared to liraglutide, leading to stronger effects on the hypothalamic appetite centers

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