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Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification

PCA revealed significant differences in DEPs between BLM+saline and CD5/ LNP groups (Fig

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We systematically evaluated plausible multi-target mechanisms, highlighted the growing importance of gutorgan crosstalk, and discussed prospective research avenuessuch as structureactivity relationship studies and synergistic combination approachesto establish a conceptual framework for advancing GLPs-derived natural therapeutics