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While the exchange reaction for protein thiols finishes within 12 min (Gl et al

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Effect of altered IGF-1R sialylation on its downstream molecules/pathways Since sialylation of the IGF-1R subunit via 2, 6 linkages is important for its conformation and ligand binding 47 , it is of interest to determine whether hyposialylation of IGF-1R affects its downstream signaling events

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