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Acta Biochim Biophys Sin 42(3):183194

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AIF is not dependent on functional caspases and could, therefore, serve as an alternative death pathway after cellular energy depletion (Broughton et al., Glial Cells and Apoptosis Neurons and cells of the oligodendroglial lineage are the most sensitive cellular elements and are damaged on the front line of ischemia or later they undergo delayed cell death