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The overall effect can add years to a persons perceived age, creating what plastic surgeons describe as a deflated or gaunt appearance that particularly concerns patients who have successfully achieved their weight loss goals

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89 OkabeM.UnnoM.HarigaeH.KakuM.OkitsuY.SasakiT.et al (2005)

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In laboratory settings, it is often used to observe how prolonged pathway activation influences cellular signaling flow, nutrient utilization patterns, and downstream growth-related pathways